Know more about Vitiligo and their associated conditions Verdura Care

Vitiligo – An auto immune condition results in loss of skin colour in patches.

Melanocytes (Pigment-producing cells) are destroyed in certain areas or stop functioning

Vitiligo affects only the external appearance
It affects people of any age, gender, or ethnic group
Not medically dangerous
Not contagious too

Sites of action

Backs of the hand
Arms
Eyes
Knees
Elbows
Feet
Mouth
Armpit
Groin
Nostrils
Umbilicus
Genitals
Rectal area

Triggers of Vitiligo

Altered immune system
Stress imbalance
A stressful event
Critical sunburn
Skin trauma
Exposure to chemicals
A neural cause
Hereditary cause
May be even a virus

Mechanism of melanogenesis

MC1R (Melanocortin 1 Receptor) gene –> MC1R (Melanocortin 1 Receptor) protein + α- MSH (Alpha – Melanin Stimulating Hormone) –> MITF (Melanocyte –Inducing Transcription Factor) –> TYR (human tyrosinase) gene –> Tyrosinase –> Dopa (dihydroxyphenylalanine) –> Dopaquinone –> Dopachrome –> Melanin 1. Eumelanin (dark colour) 2. Pheomelanin (light colour)

Vitiligo is because of absence of this mechanism either missing or misleading of any of the factors responsible for this process. Not only these factors other external triggers like oxidative stress which reduce the stability of Tyrosinase gene, which regulates melanin production. Impaired melanocyte growth and development which reduces E-cadherin expression and alters Wnt pathway responsible for melanocyte diffrentiation.

Associated problems with vitiligo

Although vitiligo is mainly a cosmetic condition, people with vitiligo may experience a variety of problems. Since there is no melanin production, which helps in protecting the skin from harmful radiations of sun, skin becomes sensitive with lack of melanin.

Skin is susceptible for skin cancers, skin rashes, skin burns, erythema( skin redness) etc..

Vitiligo can affect the colour of the eyes (iris) and also can cause abnormalities like inflammation in retina, which has light sensitive cells but affect vision.

Since Vitiligo is because of weaker immune system, more prone to autoimmune disorders like hypothyroidism, diabetes, pernicious anemia, Addison’s disease, and alopecia areata. Also people with autoimmune disorder may have chances of getting Vitiligo.

People with Vitiligo have low self esteem which leads to stress and depression making the immune system more weak.

Treat Vitiligo naturally

Verdura Mela Pro cream and Verdura mela gain cream

Verdura mela pro cream, a Natural Psoralen acts as a ‘step up transformer’ to entrap the goodness of sun light and UV radiation to augment the success of Vitiligo and Psoriasis treatments.

It has following benefits