Vitiligo – An auto immune condition results in loss of skin colour in patches.
Melanocytes (Pigment-producing cells) are destroyed in certain areas or stop functioning
- Vitiligo affects only the external appearance
- It affects people of any age, gender, or ethnic group
- Not medically dangerous
- Not contagious too
Sites of action
- Backs of the hand
- Arms
- Eyes
- Knees
- Elbows
- Feet
- Mouth
- Armpit
- Groin
- Nostrils
- Umbilicus
- Genitals
- Rectal area
Triggers of Vitiligo
- Altered immune system
- Stress imbalance
- A stressful event
- Critical sunburn
- Skin trauma
- Exposure to chemicals
- A neural cause
- Hereditary cause
- May be even a virus
Mechanism of melanogenesis
MC1R (Melanocortin 1 Receptor) gene –> MC1R (Melanocortin 1 Receptor) protein + α- MSH (Alpha – Melanin Stimulating Hormone) –> MITF (Melanocyte –Inducing Transcription Factor) –> TYR (human tyrosinase) gene –> Tyrosinase –> Dopa (dihydroxyphenylalanine) –> Dopaquinone –> Dopachrome –> Melanin 1. Eumelanin (dark colour) 2. Pheomelanin (light colour)
Vitiligo is because of absence of this mechanism either missing or misleading of any of the factors responsible for this process. Not only these factors other external triggers like oxidative stress which reduce the stability of Tyrosinase gene, which regulates melanin production. Impaired melanocyte growth and development which reduces E-cadherin expression and alters Wnt pathway responsible for melanocyte diffrentiation.
Associated problems with vitiligo
Although vitiligo is mainly a cosmetic condition, people with vitiligo may experience a variety of problems. Since there is no melanin production, which helps in protecting the skin from harmful radiations of sun, skin becomes sensitive with lack of melanin.
Skin is susceptible for skin cancers, skin rashes, skin burns, erythema( skin redness) etc..
Vitiligo can affect the colour of the eyes (iris) and also can cause abnormalities like inflammation in retina, which has light sensitive cells but affect vision.
Since Vitiligo is because of weaker immune system, more prone to autoimmune disorders like hypothyroidism, diabetes, pernicious anemia, Addison’s disease, and alopecia areata. Also people with autoimmune disorder may have chances of getting Vitiligo.
People with Vitiligo have low self esteem which leads to stress and depression making the immune system more weak.
Treat Vitiligo naturally
Verdura Mela Pro cream and Verdura mela gain cream
Verdura mela pro cream, a Natural Psoralen acts as a ‘step up transformer’ to entrap the goodness of sun light and UV radiation to augment the success of Vitiligo and Psoriasis treatments.
It has following benefits
- Contains Natural form of psoralens.
- Greater benefit in less photogenic reaction.
- Increases the susceptibility of skin to UV rays.
- Kindles genetic memory of the skin to produce melanin in Vitiligo.
- Proven to be hypoallergenic and safe for long term use
Verdura mela gain cream possess anti-oxidant effect that restores and protects natural skin colour with sun protection.
Proven to inhibit the common triggers of Vitiligo like
- Decrease in melanogenesis and tyrosinase enzyme activity
- Poor formation and decreased functioning of dendrite cells
- Reduced synthesis of tyrosinase
- Melanocyte damage due to free radicals
Hence, it is ideal as a Vitiligo treatment cream skin colour restoration cream.
