Melanin is a skin pigment that not only gives colour to the skin also protects skin cells from UVB radiation damage, reducing the risk of folate depletion, dermal degradation and increased risk of malignant melanoma, a cancer of melanocytes (melanin cells) and wholly creates a protective layer from the Sun/UV rays.

A condition where melanin is scarcely found in skin called Vitiligo, there are high chances of getting the above mentioned damages to the skin, so it is important to use any product that will absorb the sun exposure and induce the melanogenesis process and at the same time, it will also protect the vitiligenous skin from over sun exposure. As over sun exposure to the depigmented skin can be harmful.

Solution from nature!

The plant Psoralea corylifolia (Babchi) contains the active constituent Psoralen which entraps and enhances the benefit of the Sun/UV rays when mild exposure is given. It makes the skin sensitive to sunlight. Sunlight being entrapped by psoralen kindles the genetic memory of the damaged melanocytes resulting into melanin production.

Vedura melapro cream – Topical Natural Psoralen – Best cream for vitiligo

              *Quick action*     *absolutely safe*

Verdura mela pro cream, a vitiligo cream which is a Natural Psoralen contains Psoralea corylifolia acts as a ‘step up transformer’ to entrap the goodness of sun light and UV radiation to augment the success of Vitiligo.

Distinctive ingredients – Distinctive benefits

Psoralen, the vital constituent present in Psoralea corylifolia enhances the photo response of skin to maximize the advantage of sun.

Quick active and fast metabolism.

Therefore, the risk of long term photo-susceptibility of skin is nil

Hypo-allergenic and non-cytotoxic

In comparison with synthetic psoralen topical psoralen (Verdura mela pro cream) is extremely safe

Trigger the process of melanogenesis

Results in faster repigmentation of skin in vitiligo conditions

Usage instructions:

• Apply Verdura mela pro cream over required areas and expose to Sun light for about 5 minutes and then wash. Continue regular use of Verdura Mela pro cream to enhance the effect of sun.
• It can be used concurrently with other active treatments, if any, for Vitiligo and Psoriasis.
• Use alternate sources of UV light if required but under the supervision of medical practitioner (when sunlight is absent or minimal).

https://www.verduracare.com/mela-pro-cream.php

http://www.jrkresearch.com/verdura-mela-pro-cream.php

The colour of human skin depends mainly on pigments present in the skin and blood flow of the skin. The most important pigment is Melanin which is synthesized by melanocyte cells. The melanosome of melanocyte chiefly synthesize the melanin.

Melanogenesis

Melanin synthesis is influenced by

• Constitutional skin colour
• U-V radiation
• Hormone

Vitiligo

Vitiligo is a hypopigmentary skin disorder mainly due to the anatomical defect of melanocytes. It is characterised as depigmented (Milky white) patches of scalloped margins in skin with autoimmune etiology and familial predisposition. Change of hair colour into white in older lesions.

Treatment of vitiligo is not very satisfactory in many cases because exact etiology for vitiligo is unknown and different patterns of vitiligo may have different pathogenesis. Distal parts of hands and soles and non-hairy parts of skin show very slow prognosis.

Photochemotherapy

Though the treatment of vitiligo is not successful, reasonable improvement can be achieved in several patients. Photochemo theraphy is one way and it forms to mainstay of therapy in vitiligo.

Photochemo therapy is use of Psoralens in combination with UVA exposure (PUVA). Depends upon the disease, either Topical (For localised disease) or Systemic (For extensive disease) therapy is used.

Both Psoralen and Light are essential for clinical improvement as either of them used singly is not beneficial.

U-V radiation

The most important stimulus for melanogenesis (Melanin synthesis) is ultra violet radiation. Pigmentation induced by light (Called Tanning) occurs in two phases ie Immediate pigmentation and Delayed pigmentation.

Immediate pigmentation caused by exposure to UVA and mainly due to

-Photo-oxidation of the preformed melanin

– Rearrangement of melanosomes

Psoralens

Psoralens are naturally occurring tricyclic furocoumarins present in a large number of plants. Noted plants are Psoralea corylifolia and Ammi majus. Psoralens are an exogenous photosensitizer followed by ultraviolet A (UVA) irradiation. The most effective form of psoralen is 8-Methoxy Psoralen (8-MOP) which is principally of plant origin.

Response

The main principle of Topical Psoralen application is to producing a photosensitizing reaction followed by pigmentation. Repigmentation is slow. It begins in perifolicular area and also periphery of lesions and gradually becomes confluent.

Advantage of Topical Psoralen

Systemic psoralen treatment produces complaints of nausea, epigastric discomfort and giddiness. But topical application has no such side effects expect phototoxicity. In Topical therapy, required dose of sunlight is less than the systemic treatment.

Dr.JRK’s  Verdura Mela Pro cream and Verdura mela gain cream

Dr.JRK’s  Verdura Mela Pro cream is the modified and modern form of classical Psoralea corylifolia containing products like Karbogi pasai (Psoralea corylifolia paste) in siidha and Avalgujadi lepam in Ayurveda.

It has following benefits

• Contains Natural form of psoralens.
• Greater benefit in less photogenic reaction.
• Increases the susceptibility of skin to UV rays.
• Kindles genetic memory of the skin to produce melanin in Vitiligo.
• Proven to be hypoallergenic and safe for long term use

Method of application

Psoralen application is followed by exposure to gradually increasing doses (till mild erythema achieved) of sunlight. For sensitivity patients, alternative days exposure is preferable. According to new studies, the best time of the day to expose the sunlight is between 9.15 – 11.15 AM and 2.30-3.30 PM because there is minimal unwanted exposure to UVB and infrared light at these times.